Estradiol Gel 0.06% is a topical hormone replacement therapy primarily prescribed to alleviate moderate to severe symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness, burning, or itching. This gel provides estrogen support by delivering estradiol transdermally, helping restore hormonal balance and promote comfort in women who are experiencing reduced natural estrogen production after menopause or following surgical removal of the ovaries. Additionally, it can sometimes be indicated to help prevent postmenopausal osteoporosis and may provide relief in certain cancer-related hormonal deficiencies when recommended by healthcare professionals.