Linaclotide is primarily used in the management of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a guanylate cyclase-C agonist, increasing intestinal fluid secretion and accelerating transit, which helps relieve symptoms like infrequent bowel movements, bloating, and abdominal discomfort. By stimulating chloride and bicarbonate secretion into the intestinal lumen, it softens stools and promotes regularity. Linaclotide is not absorbed systemically, making its action localized to the gastrointestinal tract. It is generally prescribed for adults and should be taken on an empty stomach before meals. Its use improves quality of life for patients struggling with persistent constipation.